142 (2014): 115–120. См. также Denise Grady, “Hot Flashes: Exploring the Mystery of Women’s Thermal Chaos,” New York Times, September 5, 2002.
8. Kronenberg, “Menopausal Hot Flashes.”
9. Лорен Брент, интервью автора; Lauren Brent et al., “Ecological Knowledge, Leadership, and the Evolution of Menopause in Killer Whales,” editorial comment, Obstetrical and Gynecological Survey 70, no. 11 (2015): 701–702.
10. Наоми Рэнс, интервью автора; Naomi E. Rance et al., “Modulation of Body Temperature and LH Secretion by Hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) Neurons: A Novel Hypothesis on the Mechanism of Hot Flushes,” Frontiers in Neuroendocrinology 34, no. 3 (2013): 211–227; N. E. Rance et al., “Postmenopausal Hypertrophy of Neurons Expressing the Estrogen Receptor Gene in the Human Hypothalamus,” Journal of Clinical Endocrinology and Metabolism 71, no. 1 (1990): 79–85.
11. N. E. Rance and W. S. Young III, “Hypertrophy and Increased Gene Expression of Neurons Containing Neurokinin-B and Substance-P Messenger Ribonucleic Acids in the Hypothalami of Postmenopausal Women,” Endocrinology 128, no. 5 (1991): 2239–2247. Обзор исследований Рэнс см. в статье Ty William Abel and Naomi Ellen Rance, “Stereologic Study of the Hypothalamic Infundibular Nucleus in Young and Older Women,” Journal of Comparative Neurology 424, no. 4 (2000): 679–688.
12. Channa Jayasena, “Neurokinin B Administration Induces Hot Flushes in Women,” Scientifi c Reports 5, no. 8466 (2015).
13. Julia K. Prague et al., “Neurokinin 3 Receptor Antagonism as a Novel Treatment for Menopausal Hot Flushes: A Phase 2, Randomised, Double-Blind, Placebo-Controlled Trial,” Lancet 389, no. 10081 (May 2017): 1809–1820. Articles on the potential new nonhormone drug include Megan Cully, “Neurokinin 3 Receptor Antagonist Revival Heats Up with Astellas Acquisition,” Nature Reviews Drug Discovery 16, no. 6 (2017): 377.
14. Heyman et al., “Alzheimer’s Disease”; V. W. Henderson et al., “Estrogen Replacement Therapy in Older Women: Comparisons Between Alzheimer’s Disease Cases and Nondemented Control Subjects,” Archives of Neurology 51, no. 9 (1994): 896–900; Tang et al., “Effect of Oestrogen.”
15. Randall S. Stafford et al., “The Declining Impact of Race and Insurance Status on Hormone Replacement Therapy,” Menopause 5, no. 3 (1998): 140–144; Watkins, The Estrogen Elixir.
16. Kate M. Brett and Jennifer H. Madans, “Differences in Use of Postmenopausal Hormone Replacement Therapy by Black and White Women,” Menopause